• 1968: Diahann Carroll, Julia
• 1971: Mary Tyler Moore, The Mary Tyler Moore Show
• 1973: Jean Stapleton, All In the Family
• 1974: Jean Stapleton, All In the Family tied with Cher, The Sonny and Cher Comedy Hour
• 1975: Valerie Harper, Rhoda
• 1976: Cloris Leachman, Phyllis
• 1977: Carol Burnett, The Carol Burnett Show
• 1978: Carol Burnett, The Carol Burnett Show
• 1979: Linda Lavin, Alice
• 1980: Linda Lavin, Alice
• 1981: Katherine Helmond, Soap
• 1982: Eileen Brennan, Private Benjamin
• 1983: Debbie Allen, Fame
• 1984: Joanna Cassidy, Buffalo Bill
• 1985: Shelley Long, Cheers
• 1986: Cybill Shepherd, Moonlighting; tied with Estelle Getty, The Golden Girls
• 1987: Cybill Shepherd, Moonlighting
• 1988: Tracey Ullman, The Tracey Ullman Show
• 1989: Candice Bergen, Murphy Brown
• 1990: Jamie Lee Curtis, Anything But Love
• 1991: Kirstie Alley, Cheers
• 1992: Candice Bergen, Murphy Brown
• 1993: Roseanne Barr, Roseanne
• 1994: Helen Hunt, Mad About You
• 1995: Helen Hunt, Mad About You
• 1996: Cybill Shepherd, Cybill
• 1997: Helen Hunt, Mad About You
• 1998: Calista Flockhart, Ally McBeal
• 1999: Jenna Elfman, Dharma and Greg

2000s

• 2000: Sarah Jessica Parker, Sex and the City
  • Jenna Elfman, Dharma & Greg
  • Calista Flockhart,Ally McBeal
  • Felicity Huffman, Sports Night
  • Heather Locklear, Spin City
  • Debra Messing, Will and Grace
• 2001: Sarah Jessica Parker, Sex and the City
  • Calista Flockhart, Ally McBeal
  • Jane Kaczmarek,Malcolm in the Middle
  • Debra Messing, Will and Grace
  • Bette Midler, Bette
• 2002: Sarah Jessica Parker, Sex and the City
  • Calista Flockhart, Ally McBeal
  • Jane Kaczmarek,Malcolm in the Middle
  • Heather Locklear, Spin City
  • Debra Messing, Will and Grace
• 2003: Jennifer Aniston, Friends
  • Bonnie Hunt, Life with Bonnie
  • Jane Kaczmarek, Malcolm in the Middle
  • Debra Messing, Will and Grace
  • Sarah Jessica Parker, Sex and the City
• 2004: Sarah Jessica Parker - Sex and the City
  • Bonnie Hunt - Life with Bonnie
  • Reba McEntire - Reba
  • Debra Messing, Will and Grace
  • Bitty Schram, Monk
  • Alicia Silverstone, Miss Match
• 2005: Teri Hatcher, Desperate Housewives as Susan Mayer
  • Marcia Cross, Desperate Housewives as Bree Van De Kamp
  • Felicity Huffman, Desperate Housewives as Lynette Scavo
  • Debra Messing, Will and Grace as Grace Adler
  • Sarah Jessica Parker, Sex and the City as Carrie Bradshaw
• 2006: Mary-Louise Parker, Weeds as Nancy Botwin
  • Marcia Cross, Desperate Housewives as Bree Hodge
  • Teri Hatcher, Desperate Housewives as Susan Mayer
  • Felicity Huffman, Desperate Housewives as Lynette Scavo
  • Eva Longoria, Desperate Housewives as Gabrielle Solis
• 2007: America Ferrera, Ugly Betty as Betty Suarez
  • Marcia Cross, Desperate Housewives as Bree Hodge
  • Felicity Huffman, Desperate Housewives as Lynette Scavo
  • Julia Louis-Dreyfus, The New Adventures of Old Christine as Christine Campbell
  • Mary Louise Parker, Weeds as Nancy Botwin
• 2008: Tina Fey, 30 Rock as Liz Lemon

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