GMP-PDE delta subunit was originally identified as a fourth subunit of rod cell-specific cGMPphosphodiesterase (PDE) (). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport[1].