GDF may stand for:

• Grateful Dead Family
• Game Definition File, a file that describes a game to the Windows Vista Games Explorer
• Game Development Framework
• Gaz de France
• GD Font, a font for use with the GD Graphics Library
• General Data Format for Biomedical Signals
• Geographic Data Files
• GEODraft Database File, a proprietary file format of the documents created by the GEODraft well log authoring application.
• Global Development Finance
• Gnutella Developers Forum
• Graphic Design File, a file produced by the Altera Quartus software as a logical design schematic
• Growth and differentiation factor - a subfamily of proteins belonging to the transforming growth factor beta superfamily
• Guides de France
• Guyana Defence Force
• Gurps Data File - An expansion file for the Gurps Character Assistant role playing aide.

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