Francis I may refer to:

• Francis I, Duke of Brittany (1414-1450, reigned 1442-1450)
• Francis I, Duke of Lorraine (1517?1545, reigned 1544?1545)
• Francis I of France (1494-1547, reigned 1515-1547)
• Francesco I de' Medici, Grand Duke of Tuscany (1541-1587, reigned 1574-1587)
• Francesco I d'Este, Duke of Modena (1644-1658)
• Francis I, Holy Roman Emperor (1708-1765, reigned 1745-1765)
• Francis II, Holy Roman Emperor, also Francis I, Emperor of Austria, (1768-1835, reigned 1804-1835)
• Francis I of the Two Sicilies (1777-1830, reigned 1825-1830)

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