Fatso is a derogatory term for someone who is overweight. "Fatso" may also refer to

• Fatso (gene), also known as FTO, a gene which as been linked to obesity and type 2 diabetes.
• Fatso (film), a 1980 film starring Dom DeLuise and Anne Bancroft.
• Fatso (2008 film), a Norwegian film from 2008.
• Fatso the wombat, pet wombat from the Australian television drama series "A Country Practice".
• Fatso the Fat-Arsed Wombat, an unofficial mascot of the Sydney 2000 Olympics.
• Fatso (online DVD rental service), an online DVD rental service in New Zealand.
• Fatso (ghost), one of Casper's uncles who are better known as The Ghostly Trio.

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