D-amino acid oxidase
D-amino acid oxidase (DAAO; also DAO, OXDA, DAMOX) is a peroxisomal enzyme containing FAD as cofactor spread from yeasts to human. It is not present in bacteria or in plants.
Its function is to oxidize D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxide.
Recently, mammalian D-amino acid oxidase has been connected to the brain D-serine metabolism and to the regulation of the glutamatergic neurotransmission. In a postmortem study, the activity of DAAO was found to be two-fold higher in schizophrenia.[1] DAAO is a candidate susceptibility gene[2] and together with G72 may play a role in the glutamatergic mechanisms of schizophrenia.[3]
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