Within the membrane-bound compartments, different intracellular pH, different enzyme systems, and other differences are isolated. This enables the cell to carry out different metabolic activities at the same time. With mitochondria, the cytosol has an oxidising atmosphere which converts NADH to NAD+. With these cases, the compartmentation is physical. For protein synthesis, all the organs used for it are relatively near one another, the nucleolus makes the ribosomes which synthesize the proteins, the rough endoplasmic reticulum (rough ER) is near the nucleus as well. The Golgi body is also near the rough ER for packaging and redistributing.