SSM Cardinal Glennon Children's Hospital is a hospital in St. Louis, Missouri named after the Catholic Cardinal John J. Glennon in the St. Louis archdiocese. Cardinal Glennon hospital first opened in 1956 and continues to be operated by SSM Health Care, sponsored by the Franciscan Sisters of Mary (formerly the Sisters of St. Mary). Cardinal Glennon is used as the main teaching hospital for the Department of Pediatrics at the Saint Louis University School of Medicine.

Cardinal Glennon is home to the Bob Costas Cancer Center, the Knights of Columbus Developmental Center for children with developmental disabilities, and the St. Louis Cord Blood Bank.