Brush Creek may refer to:

In California:

• Brush Creek (Sonoma County, California)

In Iowa:

• Brush Creek (White Breast Creek), a stream in the Des Moines River catchment

In Minnesota:

• Brush Creek Township, Minnesota

In Missouri:

• Brush Creek (Missouri)

In Ohio:

• Brush Creek Township, Ohio (four different townships)
• Ohio Brush Creek

In Oklahoma:

• Brush Creek, Oklahoma

In Oregon:

• Brush Creek (Curry County, Oregon)

In Pennsylvania:

• Brush Creek (Raystown Branch Juniata River)
• Brush Creek (Shaffer Creek)
• Brush Creek (Wills Creek)
• Brush Creek Township, Pennsylvania
• Brush Creek Cemetery, outside of Irwin, Pennsylvania

In Utah:

• Brush Creek (Utah), a tributary of the Green River