The Brugada syndrome is a genetic disease that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. It is also known as Sudden Unexpected Death Syndrome^[1] (SUDS), and is the most common cause of sudden death in young men without known underlying cardiac disease in Thailand and Laos^[2].

Although the ECG findings of Brugada syndrome were first reported^[3] among survivors of cardiac arrest in 1989, it was only in 1992 that the Brugada brothers^[4] recognised it as a distinct clinical entity, causing sudden death by causing ventricular fibrillation (a lethal arrhythmia) in the heart.

Genetics and pathophysiology

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