Epstein grew up in Novarodok, where his father was the communal rabbi, but moved to the city of Pinsk after his marriage and lived there until his death, apart from a period from 1923 to 1926, which he spent in the United States of America looking (unsuccessfully) for a rabbinic position. During this period he served as the first menahel (director) of Ezras Torah from around 1924 until he was succeeded by Rav Henkin around the year 1925.
Torah Temimah ("The Perfect Torah", a reference to Psalms 19:8) - a commentary on the Torah citing all quotes of a particular verse in the Oral Torah (Talmud or Midrash), and giving textual explanations.
Baruch she-Amar ("Praised He Who Spoke", a reference to the opening paragraph of the Verses of Praise, daily morning prayers) - a commentary on the siddur (Jewish prayerbook).
Mekor Baruch ("Source of Blessing") - autobiographical work with notes on life in the Volozhin yeshiva and his uncle. Selections were translated as "My Uncle the Netziv" (see below).
Tosefet Beracha ("Added Blessing") - novellae on the Torah