An aquaretic is a class of drug that is used to promote aquaresis. They are not strictly speaking diuretics, but are sometimes classified as such.

Herbal aquaretics include adonis, agrimony, bearberry, buchu, dandelion, heartsease, hydrangea, lady's mantle, larch, and sassafras. These increase blood flow to the kidneys without increasing sodium and chloride resorption, thus causing an increase in urine whilst retaining electrolytes. However, the increase in intravascular fluid volume that they cause translates into an increase vascular resistance, and higher blood pressure.^[1]

Synthetic aquaretics, a new class of drug, are V2 receptor antagonists, such as OPC-31260. These have been used in clinical trials as a treatment for Syndrome of inappropriate antidiuretic hormone (SIADH).^[2][3]

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