Alternation may refer to:

• Alternation (card game)
• Alternation (linguistics), a variation in the phonological form of a morpheme
• Diathesis alternation
• Alternation (algorithms), see Alternating Turing machine
• R/N alternation, see Rhotacism
• AlterNation, a show on NE1 FM
• Alternation (geometry), a geometric operation for deriving polytopes from other polytopes.

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