Structure of ATP synthase, the F₀ proton channel and rotating stalk are shown in blue, the F₁ synthase domain in red and the membrane in grey.

ATP synthase delta subunit is a subunit of bacterial and chloroplast ATPase, or OSCP (oligomycin sensitivity conferral protein) in mitochondrial ATPase (note that in mitochondria there is a different delta subunit, ).

The OSCP/delta subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex. In mitochondria, the peripheral stalk consists of OSCP, as well as F0 components F6, B and D. In bacteria and chloroplasts the peripheral stalks have different subunit compositions: delta and two copies of F0 component B (bacteria), or delta and F0 components B and B (chloroplasts)^[1].

Human delta subunit of ATP synthase is coded by gene ATP5O.

References

Further reading

• [1]. Structure and arrangement of the delta subunit in the E. coli ATP synthase (ECF1F0). Wilkens S, Rodgers A, Ogilvie I, Capaldi RA; Biophys Chem 1997;68:95-102.