April 27 - Battle of Bicocca: French and Swiss forces under Odet de Lautrec are defeated by the Spanish in their attempt to retake Milan, and are forced to withdraw into Venetian territory.
ChineseMing Dynasty records indicate that the War Ministry official He Ru is the first to acquire the Portuguesebreech-loadingculverin, while copies of them are made by two Westernized Chinese at Beijing, Yang San (Pedro Yang) and Dai Ming.