Year 1466 was a common year starting on Wednesday (link will display the full calendar) of the Julian calendar.

Events of 1466

• August 26 - A conjure against Piero di Cosimo de' Medici, led by Luca Pitti and Borso d'Este, is discovered in Florence.
• October 19 - The Thirteen Years' War ends with the Second Peace of Thorn (1466)
• The Chimú Empire is conquered by troops of the Inca.
• Erik Axelsson Tott replaces Jöns Bengtsson Oxenstierna as Regent of Sweden.
• The first printed German language Bible is produced.

Births

• February 11 - Elizabeth of York, queen of Henry VII of England (d. 1503)
• June 18 - Ottaviano Petrucci, Italian music printer (d. 1539)
• August 10 - Francesco II Gonzaga, Marquess of Mantua (d. 1519)
• September 9 - Ashikaga Yoshitane, Japanese shogun (d. 1523)
• October 27 - Erasmus, Dutch philosopher (d. 1536)
• November 30 - Andrea Doria, Italian naval leader (d. 1560)
• probable
  • Moctezuma II, Aztec ruler of Tenochtitlán (d. 1520)
  • Alonso de Ojeda, Spanish conquistador and explorer (d. 1515)

Deaths

• March 8 - Francesco I Sforza, Duke of Milan (b. 1401)
• October 30 - Johann Fust, German printer (b. c. 1400)
• December 13 - Donatello, Italian artist (b. 1386)
• date unknown
  • Benedetto Accolti, Italian jurist and historian (b. 1415)
  • Hac? I Giray, first ruler of the Crimean Khanate
  • Barbara Manfredi, Italian noblewoman
  • Nicolaus Zacharie, composer

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